The Effect of Storage Conditions on the Absorption Profile of 2% Lydocaine Hydrochloridum Injection by UV-Vis Spectrophotometry

Dian Marlina; Sephia Febriyanti; Arsyeni Destra Anarchy Arsyandi; Nur Anggreini Dwi Sasangka

doi:10.26877/asset.v5i1.14937

The Effect of Storage Conditions on the Absorption Profile of 2% Lydocaine Hydrochloridum Injection by UV-Vis Spectrophotometry

Dian Marlina, Sephia Febriyanti, Arsyeni Destra Anarchy Arsyandi, Nur Anggreini Dwi Sasangka

Abstract

Lidocaine HCl injection is a sterile product that is easily contaminated when opened. The temperature and humidity in the injection storage conditions also affect the quality of the drug when viewed from the UV-Vis spectrophotometric absorption value. The aimed of this study is to find out how the effect of storage conditions on the absorption profile of 2% lydocaine HCl injection by UV-Vis spectrophotometry. The study used 27 ampoules of 2% lidocaine HCl injection and was qualitatively analyzed using UV-Vis spectrophotometry. The study lasted for 14 days by first storing the injections in storage conditions at room temperature (25-27℃), cold temperatures (5-10℃), and exposed to Ultraviolet light (380 nm). Based on the results of laboratory tests, the most suitable storage condition used for storing lidocaine HCl injection was cold storage (5-10℃) because there was no shift in the maximum wavelength as occurred during the 14^th day of UV exposure storage.

Keywords

Absorption Profile; Lydocaine HCl; Storage condition; UV-Vis Spectrophotometry

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DOI: https://doi.org/10.26877/asset.v5i1.14937

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Advance Sustainable Science, Engineering and Technology (ASSET)

E-ISSN: 2715-4211
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